Ready 2 Rumble Boxing is a boxing video game developed by Midway and published in 1999 for the Dreamcast, PlayStation, Game Boy Color, and Nintendo 64. The success of the Dreamcast version led to it becoming one of the few Sega All Stars titles. Like Nintendo's Punch-Out!! series, it features many characters with colorful personalities (i.e. Afro Thunder, Boris "The Bear" Knokimov, etc.); however, unlike the Punch-Out!! series, Ready 2 Rumble Boxing is in 3D, thus allowing for more control over one's character in the ring. Also unlike Punch-Out!!, players can choose whichever fighters they want from a rather large selection. Throughout the fights in the game, there is a special RUMBLE meter which fills up, one or two letters at a time, until the word "RUMBLE" is spelled at the bottom of the screen. Letters can be obtained by successfully landing hard blows; most such actions will yield one letter, though some particularly strong punches may yield more. Once the meter is full, the player can power himself up, enabling access to a special combo called "Rumble Flurry", activated by pressing a button combination. Each character's "flurry" is unique to them, and consists of a series of punches which does a large amount of damage if landed successfully. One unique graphic feature of the game is the gradual bruises gained by players as the fight progresses (like hematomas and swellings), present in all fifth-generation versions. While this is not necessarily a new feature to games (it had been implemented before in SNK's 1992 game Art of Fighting), it garnered much appraisal from reviewers, because of the added fun factor this element supply to the game. The Game Boy Color version was one of very few GBC games to feature built-in rumble. The Dreamcast, PlayStation and Nintendo 64 versions each have a fighter unique to them: these are, respectively, Jimmy Blood, Gino Stiletto and J.R. Flurry. Ring announcer Michael Buffer appears in the game as himself. The game was followed by a sequel in 2000 called Ready 2 Rumble Boxing: Round 2, and was later followed by a third game in the series, Ready 2 Rumble: Revolution, released on March 17, 2009. Afro Thunder features in TNA Impact! upon gaining 750,000 style points.

Rescue Heroes was initially a line of toys from Fisher-Price introduced in 1997. Rescue Heroes depicts various rescue personnel and their equipment. In 1999 an animated television series of the same name debuted. A film titled Rescue Heroes: The Movie was released in 2003, and it was based on the TV series.

Resident Evil Gaiden, known as Biohazard Gaiden in Japan, is an action-adventure game for the Game Boy Color co-developed by Capcom and M4, and first released on December 14, 2001. Received generally unfavorably by critics, the game marks a departure from other entries in the series, insofar as areas are explored with the playable character seen from a top-down perspective, with battles fought in first-person view. The story revolves around a viral outbreak on a passenger ship and has Leon S. Kennedy and Barry Burton return as protagonists.